Jul 14, 2015 · Interleukin (IL)-4 and IL-13 were among the first cytokines described in the early 1980s. The discovery and study of their structure, receptors ...
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Jun 11, 2015 · Notch-mediated signaling likely influences Th2 cytokine expression by regulating both il4 and gata3 gene transcription [65, 66]. It was ...
Mar 6, 2020 · The cytokines interleukin (IL)-4 and IL-13, signaling via the IL-4 receptor (IL-4R), orchestrate type 2 immunity to helminth infections and ...
The fully assembled receptor complex then activates the STAT6 transcription factor, but like IL-4 via the type II IL-4 receptor, IL-13 is a poor inducer of IRS ...
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It has been shown that the chemokine receptors, CCR-5 and CCR-3, act as cofactors for virus entry into macrophages, whereas the LESTR/SDF-1 receptor is required ...
Dec 2, 2020 · Cytokine storm, a life-threatening disorder involving cytokine elevations and immune-cell hyperactivation, has various causes and is ...
Mar 10, 2022 · Research on CAR T-cell therapy is progressing rapidly to improve the cancer treatment, expand its use to more cancers, and better manage its ...
When the virus enters the host, it must escape from the physical barrier of the mucosa, which is an important factor in activating the innate immune response [ ...
Here, we biophysically and structurally characterize the full-length, transmembrane form of a quaternary cytokine receptor complex consisting of gp130, LIF-R, ...
Abstract. Cytokines released from innate immune cells play key roles in the regulation of the immune response. These intercellular messengers are the sourc.